A human-demon hybrid born to the legendary demonic knight, Sparda and a human woman named Eva. He runs a handyman shop called "Devil May Cry" and hunts down demons in his free time to take revenge for his mother's death. With his father's sword, Force Edge, and a pair of handguns called Ebony and Ivory (his own creations), Dante is a force to be reckoned with who is feared by demons everywhere.

A beautiful woman who resembles Dante's mother. She stops by his "Devil May Cry" shop one day and requests that he travel to Mallet Island to prevent the demon Emperor Mundus' impending invasion of the human world.
This mysterious tight-lipped woman is actually a demon created by Mundus to kill Dante, but as she follows him around the island, she begins to warm to him.

A mysterious demonic knight cloaked in jet black armour who uses stylish sword attacks that are very similar to Dante's. Nelo Angelo is actually Dante's brother, Vergil. He once challenged Mundus, but he lost and was repurposed into one of Mundus' underlings. As his brutal battles with Dante unfold, Vergil's lost memories begin to resurface, causing him great anguish.

The Prince of Darkness himself (not Ozzy Osbourne anymore I guess, lol). He led an army of demons in an invasion of the human world 2000 years ago. Mundus was defeated by Sparda at the time, but was revived just 20 years ago. After killing Dante's mother, he retreated to Mallet Island to plan another invasion of the human world. Realizing the threat Dante poses, Mundus sends Trish to his shop in order to lure him to the island.

A legendary demonic knight who betrayed the demon world and killed the Demon Emperor Mundus 2000 years ago. He came to be praised as a hero for this, and eventually married a human woman named Eva, and fathered Dante and Vergil.

Mother of Dante and Vergil and wife of Sparda. She is a human and has been a strong motherly figure to the twins until her death at the hands of Mundus' demons.