Dante (as well as himself from Viewtiful Joe) -> Drew Coombs
Trish and Eva (Dante's Mother) -> Sarah Lafleur
Nelo Angelo (Vergil) -> David Keeley
Mundus -> Tony Daniels
Phantom and Griffon -> Howard Jerome
Young Dante and Young Vergil -> Jonathan Mallen
Dante (as well as himself from Shin Megami Tensei) -> Matthew Kaminsky
Lucia -> Francoise Gralewsky
Matier -> Flo Di Re
Arius -> Sherman Howard
Dante (as well as himself from Marvel vs CAPCOM 3) -> Reuben Langdon
Vergil (as well as himself in Ultimate Marvel vs CAPCOM 3) -> Daniel Southworth
Lady -> Kari Wahlgren
Enemies and Most Bosses -> Larry Leong
Arkham and Jester -> Adam D. Clerk
Nevan -> Mary Elizabeth McGlynn
(There was a Russian voice cast as well. Cannot find the information for who voiced as them in Russian.)
Nero -> Johnny Yong Bosch
Japanese voice - Kaito Ishikawa
Dante -> Reuben Langdon
Japanese voice - Toshiyuki Morikawa (Also voiced as him in Ultimate Marvel vs CAPCOM 3 and the Project X-Zone series)
Vergil -> Daniel Southworth
Japanese voice - Hiroaki Hirata (Also voiced as him in Ultimate Marvel vs CAPCOM 3 and the Project X-Zone series)
Kyrie -> Stephanie Sheh
Credo -> T.J Rotolo
Sanctus -> Liam O'Brian
Agnus -> T.J Storm
Lady -> Kari Wahlgren (Original DMC4)
-> Kate Higgans (DMC4: Special Edition)
Japanese voice - Fumiko Orikasa (Also voiced as her in the Project X-Zone series)
Trish/Gloria (as well as herself from Marvel vs CAPCOM 3 ;)) -> Danielle Burgio
Japanese voice - Atsuko Tanaka
Enemies and Most Bosses -> Larry Leong
Echidna -> Mary Elizabeth McGlynn
(There was a German voice cast as well. Cannot find the information on who voiced as them in German.)
Dante -> Reuben Langdon
Japanese voice - Toshiyuki Morikawa
Patty -> Hilary Haag
Japanese voice - Misato Fukuen
Morrison -> Rob Mungle
Japanese voice - Akio Ohtsuka
Lady -> Melissa Davis
Japanese voice - Fumiko Orikasa
Trish -> Luci Christian
Japanese voice - Atsuko Tanaka
Sid -> Chris Ayres
Japanese voice - Nachi Nozawa